Thseparation Tb. Nthickness Tb. SD at both sites; the opposite was true in the outer-anterior OA subregion at the distal radius and the outer-medial OM and -posterior OP subregions at the distal tibia. The variation in these parameters as a function of resolution, and the relationship between the structural parameters, bone mineral density and the elastic modulus are also examined.
Using a standardized thresholding criterion for all images we find that there is an overestimation of trabecular bone area fraction approximately 3 timestrabecular width approximately 3 timesfractal dimension approximately 1. The XTM image resolution is similar to that obtained from histomorphometric sections 18 microns isotropicwhile the MR images are obtained at a resolution comparable to that achievable in vivo x x microns.
Th, and low Tb. Abstract The contribution of trabecular bone structure to bone strength is of considerable interest in the study of osteoporosis and other disorders characterized by changes in the skeletal system. In this in vitro study we compare the measures of trabecular structure obtained using MR imaging and higher-resolution X-ray tomographic microscopy XTM imaging of cubes from human distal radii.
Therefore, a combined approach of investigating the entire region, each subregion, and the cortical compartment may offer more complete information.
However, even for a factor of 9 difference in spatial resolution, the differences in the morphological trabecular structure measures ranged from a factor of 1. Gender differences were most pronounced in the inner-anterior IA subregion compared to the other regions or the global mean differences at both sites.
Spand heterogeneity Tb. Magnetic resonance MR imaging of trabecular bone has emerged as a promising technique for assessing trabecular bone structure. Substantial regional variations in trabecular bone structure at the distal radius and tibia were revealed e.
This preliminary study indicates that measures of trabecular bone structure using MR imaging may play a role in the study of osteoporosis. In MR images, because the resolution is comparable to the trabecular dimensions, partial volume effects occur, which complicate the segmentation of the image into bone and marrow phases.
This study demonstrated that not only the conventional global analysis can obscure regional differences, but also assuming bone status from that of smaller subregion may introduce a confounding sampling error. Previous article in issue.
Trabecular structure associated with age and differed between young and elderly adults predominantly in the inner-posterior IP subregion at the distal radius and in the IL and IA subregions at the distal tibia; on the other hand, it remained unchanged in the OA subregion at the distal radius and in the OM subregion at the distal tibia for both women and men.
SD were obtained in a total of 11 regions—the entire trabecular compartment the global meansinner, outer, and eight defined subregions.
A preliminary bivariate analysis showed that in addition to bone mineral density alone, the Betti number, trabecular number and spacing contributed to the prediction of the elastic modulus. The objective of this study is to characterize spatial variability in trabecular structure within a cross-section at the distal radius and tibia, and gender and age effects using in vivo high-resolution peripheral quantitative computed tomography HR-pQCT.
Regional variations were examined with respect to the global means, and compared between women and men, and between young 20—29 years old and elderly 65—79 years old adults.Regional variations of gender-specific and age-related differences in trabecular bone structure of the distal radius and tibia.
ture groups in the total femur BMD ~13%!, trabecular BMD in the distal radius ~4%!, and the fractal dimension in the radiographs ~FD2!~3%!. The correlations between FD2 and the total femur BMD as well as trabecular bone BMD in the distal radius were (p,) and (p,); respectively; FD1 increased with BMD and showed lower correlations.
In vivo assessment of trabecular bone structure at the distal radius from high-resolution computed tomography images.
Kalpakcioglu, B., Engelke, K. and Genant, H. (). Advanced imaging assessment of bone fragility in glucocorticoid-induced osteoporosis. bone mineral density (BMD) of the distal radius were measured using DXA.
Cortical and trabecular structural measures of the distal radius were computed in high-resolution T MR images. Cortical measures included average cortical thickness and cross-sectional area.
Trabecular measures included morphometric and texture parameters. It is well known that the trabecular bone density is the greater at distal sites of the radius and decreases proximally.
These variations were reflected by the decreases in the trabecular width. fractional area and fractal dimension. Bone Structure at the Distal Radius During Adolescent Growth (10) Studies using pQCT at the distal radius found no changes in trabecular volumetric BMD our data suggest that T may regulate the development of trabecular structure and bone size in boys during puberty.Download